Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
EUR
Contact rapide
Veuillez m'envoyer plus d'informations sur
Fmoc-L-Ala(BCP)-OH
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-3-(bicyclo[1.1.1]pentan-1-yl)-L-alanine // Synonymes: Fmoc-Ala(BCP)-OH, 3-Bicyclo[1.1.1]pent-1-yl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid
- n° Art.:SCX1240
- n° CAS:2095488-98-3
- Formule:C23H23NO4
- Masse moléculaire:377,43 g/mol
Starting at Sur demande
description
Phenol groups bearing drugs suffer rapid first-pass metabolism to glucuronide and sulfate conjugates, resulting in low bioavailability and low plasma concentrations.
An isosteric and biocompatible replacement of phenyl rings is the BCP moiety (bicyclo[1.1.1]pentane). This hypothesis has been successfully demonstrated in the case of Resveratrol: BCP-Resveratrol shows significantly improved half-life in plasma and intrinsic clearance. Metabolite formation, like glucuronide and sulfate conjugation is drastically reduced.
references
Toward Resolving the Resveratrol Conundrum: Synthesis and in Vivo Pharmacokinetic Evaluation of BCP–Resveratrol. Y. L. Goh, Y. T. Cui, V. Pendharkar, and V. A. Adsool; ACS Med. Chem. Lett. 2017; 8: 516-520. https://doi.org/10.1021/acsmedchemlett.7b00018.
A practical metal-free homolytic aromatic alkylation protocol for the synthesis of 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid. N. T. Thirumoorthi, V. A. Adsool; Org. Biomol. Chem. 2016; 14: 9485-9489. https://doi.org/10.1039/c6ob01799a.
Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene. N. T. Thirumoorthi, C. J. Shen, V. A. Adsool; Chem. Commun. 2015; 51: 3139-3142. https://doi.org/10.1039/C4CC09655J.
Radical fluorination powered expedient synthesis of 3-fluorobicyclo[1.1.1]pentan-1-amine. Y. L. Goh and V. A. Adsool; Org. Biomol. Chem. 2015; 13: 11597-11601. https://doi.org/10.1039/C5OB02066B.
A New Route to Bicyclo[1.1.1]pentan-1-amine from 1-Azido-3-iodobicyclo[1.1.1]pentane. Y. L. Goh, E. K. W. Tam, P. H. Bernardo, C. B. Cheong, C. W. Johannes, A. D. William, and V. A. Adsool; Org. Lett. 2014; 16: 1884-1887. https://doi.org/10.1021/ol500635p.
Commande groupée?
Vous avez besoin de plus grandes quantités pour votre développement ou production?
Besoin d'informations supplémentaires sur ce produit?
entrer en contact
Related Products
Des produits qui pourraient également vous intéresser!
![(Boc-NH-7,7-Me2-BChept-3-yl]acetic acid (R,R,S,S)](https://development.iris-biotech.de/media/catalog/product/B/A/BAA2690_14.svg?width=216&height=140&store=fr&image-type=small_image)
![(Boc-NH-7,7-Me2-BChept-3-yl]acetic acid (R,R,S,S)](https://development.iris-biotech.de/media/catalog/product/B/A/BAA2690_13.svg?width=216&height=140&store=fr&image-type=small_image)
