Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
EUR
Contact rapide
Veuillez m'envoyer plus d'informations sur
Fmoc-N-propargyl-MPBA
Nom chimique: 4-(4-(((9-Fluorenylmethyloxycarbonyl)(propargyl)amino)methyl)-3-methoxyphenoxy)butanoic acid // Synonymes: 4-(4-(((((9H-fluoren-9-yl)methoxy)carbonyl)(prop-2-yn-1-yl)amino)methyl)-3-methoxyphenoxy)butanoic acid, 4-(3-methoxy-4-[(Fmoc)(propargyl)aminomethyl]-phenoxy-butanoic acid
- n° Art.:RL-3780
- n° CAS:1009362-00-8
- Formule:C30H29NO6
- Masse moléculaire:499,20 g/mol
Starting at Sur demande
description
A propargyl-substituted MPBA linker derived from 4-hydroxy-3-methoxybenzaldehyde, which can be elongated using standard Fmoc-based solid phase chemistry and linked to supports by standard coupling procedures. The benzylic bond can be cleaved by addition of 90% TFA with appropriate scavengers.
This linker is reported to enable access to triazole-containing cyclic pseudopeptides.
references
Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations; I. E. Valverde, F. Lecaille, G. Lalmanach, V. Aucagne, A. F. Delmas; Angew. Chem. Int. Ed. Engl. 2012; 51(3): 718-722. https://doi.org/10.1002/anie.201107222.
Biomimetic Screening of Class-B G Protein-Coupled Receptors; C. Devigny, F. Perez-Balderas, B. Hoogeland, S. Cuboni, R. Wachtel, C. P. Mauch, K. J. Webb, J. M. Deussing, F. Hausch; J. Am. Chem. Soc. 2011; 133(23): 8927-8933. https://doi.org/10.1021/ja200160s.
Backbone Amide Linker Strategy for the Synthesis of 1,4-Triazole-Containing Cyclic Tetra- and Pentapeptides; J. Springer, K. R. de Cuba, S.
Calvet-Vitale, J. A. J. Geenevasen, P. H. H. Hermkens, H. Hiemstra, J. H. van Maarseveen; Eur. J. Chem. 2008; 15: 2592-2600. https://doi.org/10.1002/ejoc.200800143.
An alternative method for the preparation of resin-bound secondary amines; R. E. Austin, C. A. Waldraff, F. Al-Obeidi; Tetrahedron Lett. 2002; 43(19): 3555-3556. https://doi.org/10.1016/S0040-4039(02)00569-5.
Commande groupée?
Vous avez besoin de plus grandes quantités pour votre développement ou production?
Besoin d'informations supplémentaires sur ce produit?
entrer en contact
Related Products
Brochures et dépliants
Des produits qui pourraient également vous intéresser!
