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Bestatin HCl
Nom chimique: N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine hydrochloride
- n° Art.:LS-3880
- n° CAS:65391-42-6
- Formule:C16H24N2O4 * HCl
- Masse moléculaire:308,38*36,45 g/mol
Starting at Sur demande
description
Reversible inhibitor of aminopeptidase enzymes. Shows no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or thermolysin.
references
Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool; A. Trochine, D. J. Creek, P. Faral-Tello, M. P. Barrett and C. Robello; Antimicrob Agents Chemother 2015; 59: 2921-5. doi:10.1128/AAC.05046-14
Enhanced anticancer activity of 5-FU in combination with Bestatin: Evidence in human tumor-derived cell lines and an H22 tumor-bearing mouse; J. Li, X. Wang, J. Hou, Y. Huang, Y. Zhang and W. Xu; Drug discoveries & therapeutics 2015; 9: 45-52. doi:10.5582/ddt.2015.01006
Proteasome inhibitors reconstitute the presentation of cytotoxic T-cell epitopes in Epstein-Barr virus-associated tumors; R. Gavioli, S. Vertuani and M. G. Masucci; Int J Cancer 2002; 101: 532-8. doi:10.1002/ijc.10653
The aminopeptidase activity in the human T-cell lymphoma line (Jurkat) is not at the cell surface and is not aminopeptidase N (CD-13); H. Murray, A. J. Turner and A. J. Kenny; Biochem J 1994; 298 ( Pt 2): 353-60.
Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells; A. Menrad, D. Speicher, J. Wacker and M. Herlyn; Cancer Res 1993; 53: 1450-5.
Aminopeptidase activity of an antitumor antibiotic, C-1027; N. Sakata, K. S. Tsuchiya, Y. Moriya, H. Hayashi, M. Hori, T. Otani, M. Nagai and T. Aoyagi; The Journal of antibiotics 1992; 45: 113-7.
Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes; H. Umezawa, T. Aoyagi, H. Suda, M. Hamada and T. Takeuchi; The Journal of antibiotics 1976; 29: 97-9.
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