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Biotin-PEG(4)-Dde-Alkyne
Nom chimique: N-(15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3,6,9,12-tetraoxa-16-azanonadec-18-ynyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide // Synonymes: Dde-Biotin-Alkyne, Dde-Biotin-PEG(4)-Alkyne, Propargyl-Dde-PEG(4)-Biotin
- n° Art.:PEG7980
- n° CAS:1802908-00-4
- Formule:C32H50N4O8S
- Masse moléculaire:650,83 g/mol
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description
This cleavable trifunctional biotinylating reagent incorporating a cleavable linker is highly valuable for usage in protein enrichment. A linker based on the Dde protecting group leads to efficient release of protein targets under mild aqueous buffered conditions with 2% hydrazine. The cleaved moiety that remains on the modified peptide only minimally changes the peptide mass and generates an additional positive charge, which facilitates peptide sequencing by ETD.
references
Cleavable trifunctional biotin reagents for protein labelling, capture and release; Yinliang Yang and Steven H. L. Verhelst; Chem. Commun. 2013; 49: 5366-5368. DOI: 10.1039/C3CC42076K.
Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag; Matthew E. Griffin, Elizabeth H. Jensen, Daniel E. Mason, Courtney L. Jenkins, Shannon E. Stone, Eric C. Peters and Linda C. Hsieh-Wilson; Mol. BioSyst. 2016; 12: 1756-1759. DOI: 10.1039/C6MB00138F.
Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes; Gertsik N, Am Ende CW, Geoghegan KF, Nguyen C, Mukherjee P, Mente S, Seneviratne U, Johnson DS, Li YM; Cell Chem Biol. 2017; 24(1): 3-8. DOI: 10.1016/j.chembiol.2016.12.006.
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