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Halo-PEG(5)-azide
Nom chimique: 1-azido-21-chloro-3,6,9,12,15-pentaoxahenicosane // Synonymes: Haloalkane Dehalogenase Ligand
- n° Art.:RL-3640
- n° CAS:1261238-21-4
- Formule:C16H32ClN3O5
- Masse moléculaire:381,90 g/mol
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description
This compound is reported as HaloTag linker ligand for the synthesis of a fluorescent pH-sensitive dye. The HaloTag is a reporter protein whose sequence can easily be fused to a gene of interest. Once expressed, this reporter protein is designed to covalently bind ligands that are composed of two parts: a reactive linker that forms the bond with HaloTag protein and a functional moiety in the form of a fluorescent dye or affinity handle. In this case, the HaloTag linker ligand is suitable for further conjugation via Click chemistry.
references
Direct pH measurements by using subcellular targeting of 5(and 6-) carboxyseminaphthorhodafluor in mammalian cells; H. A. Benink, M. G. McDougall, D. H. Klaubert, G. V. Los; Biotechniques 2018; 47(3): 769-774. https://doi.org/10.2144/000113220.
Preparaion of purine derivatives for treating cancer; H. Arimoto, K. Itto, D. Takahashi, N. Cho, H. Nara, K. Shimokawa, O. Kenichiro, S. Taiichi, I. Shigekazu, N. Ishii; PCT Int. Appl. 2018; WO2018143403A1.
HaloTag technology: a versatile platform for biomedical applications; C. G. England, H. Luo and W. Cai; Bioconjug Chem 2015; 26: 975-86. https://doi.org/10.1021/acs.bioconjchem.5b00191.
HaloTag: a novel protein labeling technology for cell imaging and protein analysis; G. V. Los, L. P. Encell, M. G. McDougall, D. D. Hartzell, N. Karassina, C. Zimprich, M. G. Wood, R. Learish, R. F. Ohana, M. Urh, D. Simpson, J. Mendez, K. Zimmerman, P. Otto, G. Vidugiris, J. Zhu, A. Darzins, D. H. Klaubert, R. F. Bulleit and K. V. Wood; ACS Chem Biol 2008; 3: 373-382. https://doi.org/10.1021/cb800025k.
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